ࡱ > =; bjbj 7n ;3 8 + 4 _ : < < < < < < $ S n ` ` u . : : 0E " & 0 c c c ` ` c : Supplementary Table 1: Clinical outcomes reported by studies comparing SRS to PRFA
AuthorType ofSurvival (%)P valueDFS (%)P valueRecurrence (%)Mortality Complications (Year)Treatment (N)T1T2T3T1T2T3T1T2T3n (%)n (%)RCTs1 y3 y4 y1 y3 y4 y1y2y3yChen ADDIN REFMGR.CITE ADDIN EN.CITE.DATA (1;2) PRFA (90)946966P> 0.05916048P> 0.05919230(0)3 (4.2)( 2006) #SRS (90)9373648770521118251(1.1)50( 55)Comparative cohort studies1 y3 y5 y1 y3 y5 yGuglielmi ADDIN REFMGR.CITE ADDIN EN.CITE.DATA (4) PRFA(109)834220P= 0.01602222P=0.001NANANA0(0)11 (10)(2008)SRS (91)846448835627NANANA0(0)33 (36)1 y3 y5y1 y3 y5yTakahashi ADDIN REFMGR.CITE ADDIN EN.CITE.DATA (7) (2007)PRFA(171)99*90*77P> 0.05Median DFS:
23 monthsP=0.075266885NANASRS (53)96*81*70Median DFS:
25 months204973NANA1y3y5y1y3y5yLupo ADDIN REFMGR.CITE Lupo200732Single hepatocellular carcinoma ranging from 3 to 5 cm: radiofrequency ablation or resection?Journal32Single hepatocellular carcinoma ranging from 3 to 5 cm: radiofrequency ablation or resection?Lupo,L.Panzera,P.Giannelli,G.Memeo,M.Gentile,A.Memeo,V.2007Disease-Free SurvivaletiologyItalyLiver TransplantationmethodsRecurrencesurgerytherapyNot in File429434HPB (Oxford)96Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari ItalyPM:18345289HPB (Oxford)1(6)PRFA (60)965332P> 0.0568180P> 0.05NANANA0(0)6 (10) (2007)SRS (42)915743743514NANANA1(2.4)7 (17)1y2y3y1y2y3y1y2y>2yCho ADDIN REFMGR.CITE Cho200524[The comparative results of radiofrequency ablation versus surgical resection for the treatment of hepatocellular carcinoma.]Journal24[The comparative results of radiofrequency ablation versus surgical resection for the treatment of hepatocellular carcinoma.]Cho,C.M.Tak,W.Y.Kweon,Y.O.Kim,S.K.Choi,Y.H.Hwang,Y.J.Kim,Y.I.2005AdultAgedAged,80 and overCarcinoma,HepatocellularCatheter AblationcomplicationsFemaleHepatectomyHumansKoreaLiver NeoplasmsMalemethodsMiddle AgedmortalityNeoplasm Recurrence,LocalpathologyRecurrencesecondarysurgerySurvival RatetherapyNot in File5971Korean J Hepatol.111Department of Internal Medicine, College of Medicine, Kyungpook National University, Daegu, Korea. cmcho@mail.knu.ac.krPM:15788886Korean J Hepatol.1(3) PRFA (99)968780P> 0.05735131P> 0.052440470(0)4 (6.5)(2005)SRS (61)9887777251372638430(0)5 (5.0)1y2y3y1y2y3y1y2y3yHong ADDIN REFMGR.CITE Hong200533Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic functionJournal33Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic functionHong,S.N.Lee,S.Y.Choi,M.S.Lee,J.H.Koh,K.C.Paik,S.W.Yoo,B.C.Rhee,J.C.Choi,D.Lim,H.K.Lee,K.W.Joh,J.W.2005Carcinoma,HepatocellularCatheter AblationFemaleHepatectomyHumansKoreaLiver Function TestsLiver NeoplasmsMaleMiddle AgedphysiopathologyRecurrencesurgerySurvival RatetherapyNot in File247252J Clin Gastroenterol.393Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, KoreaPM:15718869J Clin Gastroenterol.1(5) PRFA (55)10088*73P> 0.05745740P> 0.0526*45*58NANA(2005)SRS (93)9892*8476635524*43*45NANA
Abbreviations: RCTs= randomized controlled trials; NA= not applicable; PRFA= percutaneous radiofrequency ablation; SRS= surgical resection; DFS =disease free survival; T1, T2, T3=time point (in years) when clinical outcomes were reported; N=Total sample size; n=number with outcome; y=year/years; Mortality= procedure related mortality or hospital mortality.
#: Originally, this paper was published in Chinese in 2005 ADDIN REFMGR.CITE Chen200516[Comparison of effects of percutaneous radiofrequency ablation and surgical resection on small hepatocellular carcinoma]Journal16[Comparison of effects of percutaneous radiofrequency ablation and surgical resection on small hepatocellular carcinoma]Chen,M.S.Li,J.Q.Liang,H.H.Lin,X.J.Guo,R.P.Zheng,Y.Zhang,Y.Q.2005Carcinoma,HepatocellularCatheter AblationChinaFemaleHumansLiver NeoplasmsMalemethodsMiddle AgedpathologyRecurrencesurgerySurvival RateTreatment OutcomeNot in File8083Zhonghua Yi Xue Za Zhi.852Department of Hepatobiliary Surgery, Tumor Hospital, Cancer Centre of Sun Yat-sen University, Guangzhou 510060, ChinaPM:15774210Zhonghua Yi Xue Za Zhi.1(1). Thereafter authors added additional patients and republished, including all patients in 2006 ADDIN REFMGR.CITE Chen20064A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinomaJournal4A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinomaChen,M.S.Li,J.Q.Zheng,Y.Guo,R.P.Liang,H.H.Zhang,Y.Q.Lin,X.J.Lau,W.Y.2006AdolescentAdultAgedCarcinoma,HepatocellularCatheter AblationFemaleFollow-Up StudiesHepatectomyHumansLiver NeoplasmsMalemethodsMiddle AgedmortalitypathologyProspective StudiessurgerySurvival RatetherapyTreatment OutcomeNot in File321328Ann Surg2433Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat-Sen University, Guangzhou, China. Cms64@21cn.comPM:16495695Ann Surg1(2) . However, the 2006 article did not report recurrence rates, so we derive these from the 2005 study ADDIN REFMGR.CITE Chen200516[Comparison of effects of percutaneous radiofrequency ablation and surgical resection on small hepatocellular carcinoma]Journal16[Comparison of effects of percutaneous radiofrequency ablation and surgical resection on small hepatocellular carcinoma]Chen,M.S.Li,J.Q.Liang,H.H.Lin,X.J.Guo,R.P.Zheng,Y.Zhang,Y.Q.2005Carcinoma,HepatocellularCatheter AblationChinaFemaleHumansLiver NeoplasmsMalemethodsMiddle AgedpathologyRecurrencesurgerySurvival RateTreatment OutcomeNot in File8083Zhonghua Yi Xue Za Zhi.852Department of Hepatobiliary Surgery, Tumor Hospital, Cancer Centre of Sun Yat-sen University, Guangzhou 510060, ChinaPM:15774210Zhonghua Yi Xue Za Zhi.1(1).
*: Estimated value, extracted from the graphs of the articles.
: in PRFA group, 89 out of 109 with complete necrosis were included in disease free survival analysis.
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